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Download Ionic Channels of Excitable Membranes, a Comprehensive Textbook on the Biophysics and Molecular Biology of Ion Channels



Download Ionic Channels of Excitable Membranes, a Comprehensive Textbook on the Biophysics and Molecular Biology of Ion Channels




Ion channels are pore-forming proteins that regulate the flow of ions across biological membranes. They are essential for many physiological processes, such as nerve conduction, muscle contraction, hormone secretion, and sensory transduction. Ion channels are also involved in many pathological conditions, such as epilepsy, cardiac arrhythmias, neurodegeneration, and pain.


Ion Channels Of Excitable Membranes Pdf Download



Understanding the structure, function, and regulation of ion channels is a major challenge for biologists, physicists, chemists, and pharmacologists. Ionic Channels of Excitable Membranes is a textbook that provides a comprehensive and authoritative overview of this fascinating field. Written by Bertil Hille, a pioneer and leader in ion channel research, this book covers the classical biophysical work of Hodgkin and Huxley, the roles of channels in cellular signaling, the physical and molecular principles of permeation, gating, pharmacological modification, and molecular diversity, and the evolution of ion channels.


The third edition of Ionic Channels of Excitable Membranes has been fully revised and expanded to include the latest research advances in structural biology, molecular biology, genomics, and calcium signaling. It also features new chapters on calcium channels, potassium channels, sodium channels, chloride channels, and proton channels. The book is written in a clear and engaging style that makes it accessible and interesting to students and researchers of all backgrounds. It is suitable for advanced undergraduate and graduate courses in neuroscience, biophysics, physiology, pharmacology, and biochemistry.


If you want to learn more about ion channels and their roles in health and disease, you can download Ionic Channels of Excitable Membranes as a PDF file from various online sources. For example:


  • You can access the book from SpringerLink[^1^], where you can also find other related books and articles.



  • You can find a PDF version of the book on Semantic Scholar[^2^], where you can also explore citations and references.



  • You can download the book from Google Drive[^3^], where you can also share it with others.



Whichever source you choose, you will find Ionic Channels of Excitable Membranes to be a valuable resource for your studies and research on ion channels.


One of the main topics of Ionic Channels of Excitable Membranes is the biophysical analysis of ion channel function. The book explains how to measure and interpret the electrical properties of ion channels, such as current-voltage relationships, conductance, selectivity, and kinetics. It also describes the mathematical models that describe the behavior of ion channels, such as the Hodgkin-Huxley equations, the Goldman-Hodgkin-Katz equation, and the Markov chain model. The book illustrates how these models can be used to understand the mechanisms of action potentials, synaptic transmission, and cellular excitability.


Another important topic of Ionic Channels of Excitable Membranes is the molecular biology and diversity of ion channels. The book discusses how ion channels are encoded by genes, how they are synthesized and processed in cells, and how they are assembled into functional complexes. It also reviews the structural features of ion channels, such as the pore-forming domains, the voltage-sensing domains, the ligand-binding domains, and the regulatory domains. The book shows how these features determine the specificity and modulation of ion channel activity. The book also explores the evolutionary origins and diversity of ion channels, and how they have adapted to different physiological roles and environments.


A third major topic of Ionic Channels of Excitable Membranes is the role of ion channels in cellular signaling and physiology. The book examines how ion channels are regulated by various factors, such as voltage, ligands, second messengers, phosphorylation, and protein-protein interactions. It also explains how ion channels mediate various cellular functions, such as membrane potential, calcium signaling, secretion, contraction, gene expression, and cell death. The book highlights the importance of ion channels in different tissues and organs, such as the nervous system, the muscular system, the endocrine system, and the immune system. The book also discusses how ion channel dysfunction can lead to various diseases and disorders. 29c81ba772


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